A young Italian, Stefan Salvatore moved to Fell's Church and stayed in Mrs. Flowers boarding house. She saw when Stefan first brought Elena Gilbert home after he saved her, and greeted Elena kindly the next day. At this point nobody was aware that she was a witch.
After Elena Gilbert, Matt Honeycutt, Bonnie McCullough and Meredith Sulez found Stefan, they took him back to the boarding house and found that Mrs. Flowers had left the front door open. They thought she was crazy to do that since there had been attacks by the cemetery which was near the boarding house.
Stefan and Damon Salvatore returned to Fell's Church after Bonnie summoned Stefan. They hid in the boarding house barn to talk but were interrupted by Mrs. Flowers who bought them refreshments and had Stefan's room ready for him, promising not to speak a word of his return before she left, leaving everyone stunned and confused.
While doing her gardening, Stefan, Matt, Meredith and Bonnie asked her where they could hide white-ash wood and she directed them to the location in the woods, confused.
She was hardly in The Return: Nightfall, due to the Dark Dimension.
Matt returned to Fell's Church and stayed at the boarding house with Mrs. Flowers. Meredith said that they made a solid team. Mrs. Flowers enjoyed Matt's company and cared very much for his safety. They worked with Dr. Alpert and Isobel Saitou 's mother and grandmother. One night Matt went and spied Shinichi with several children, including the Sheriff's niece Rebbecca (Do not get confused with Rebekah Mikaelson). The sheriff went after them abut did not return, and Matt later saw Rebbecca wearing his shirt as a dress. Matt snatched the sheriff's badge from her and took it back to Mrs. Flowers who tried to see what happened to the sheriff through the badge, but could not see clearly since it hadn't been touching his skin.
In the series she runs only a small bed and breakfast which Katherine prefers.
She was portrayed by Jackie Prucha.
Theophilia is of Greek origin, and the meaning is "loved by God".
- Theophilia Flowers is not described in detail in the original series, however in the 1996 game, she looks like a nice and loving lady.
- Compared to novels, in the TV Series, Mrs. Flowers shows a much older, and she is not a supernatural being.
- Possibly, Sheila Bennett is the combination of roles in the novels of Mrs. Flowers and Honoria Fell.
- Theophilia Flowers suggested that Inari may have been behind Katerina von Swartzschild, Klaus, and Tyler Smallwood, although she claimed that she did not need "pawns". If Flowers was correct, this would likely make Inari the true antagonist of the first two story arcs.